Effect of curcumin on the protein expression of pleiotrophin in cervical cancer caski cells
- VernacularTitle:姜黄素对宫颈癌Caski细胞中Pleiotrophin蛋白表达的影响
- Author:
Tingting FAN
- Publication Type:Journal Article
- Keywords:
Curcumin;
Pleiotrophin;
Cervical cancer
- From:
Journal of Chongqing Medical University
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of curcumin on the proliferation and the protein expression of Pleiotrophin(PTN) in cervical cancer Caski cells. Methods:MTT was used to assay the proliferation of Caski cells which were treated with different concentrations of curcumin. The immunocytochemistry was used to assay the distinctive expression of PTN in Caski cells which were treated by curcumin or not. The effects of curcumin with different concentrations on the protein levels of PTN were tested by Western blotting. Results:The proliferation of Caski cells were inhibited by curcumin in a does-dependent manner.Immunocytochemistry assessment showed the expression of PTN was significant down-regulated after treated with curcumin. Western blotting showed the curcumin could down-regulate the expression of PTN,and this was a does-dependent action. Conclusion:Curcumin could inhibit the proliferation and the PTN expression of Caski cells significantly,which may be one of the molecular mechanisms anticancer of curcumin.
