Preparation of curcumin solid lipid nanoparticles by film-ultrasonic method
- VernacularTitle:薄膜-超声法制备姜黄素固体脂质纳米粒的工艺研究
- Author:
Yan MA
- Publication Type:Journal Article
- Keywords:
curcumin;
solid lipid nanoparticles;
film-ultrasonic wave dissolving technique;
preparing technique
- From:
Chinese Traditional Patent Medicine
1992;0(07):-
- CountryChina
- Language:Chinese
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Abstract:
AIM: To optimize technique for preparing curcumin solid lipid nanoparticles by film-ultrasonic dispersion. METHODS: The influence of various factors,including the consumption of curcumin,stearic acid,lecithin and tween-80,and their effects on the entrapment efficiency and the ratio of loading drug were investigated.And the optimum formula was selected through uniform design test. RESULTS: Under the condition of 30 mg of curcumin,60 mg of lecithin,117 mg of stearic acid and 10 mL of tween-80(1.0%) curcumin solid lipid nanoparticals had good size distributions.The mean particle size diameter was 58.0 nm and the average entrapment efficiency and the ratio of loading drug approached 95.98% and 15.87%,respectively. CONCLUSION: The technique for preparing curcumin solid lipid nanoparticals N by film ultrasonic method is feasible.
