In vitro evaluation of indirubin self-emulsifying drug delivery system
- VernacularTitle:靛玉红自乳化释药系统的体外评价
- Author:
Jun LEI
- Publication Type:Journal Article
- Keywords:
indirubin;
self-emulsifying drug delivery systems;
time of self-emulsifying;
dissolution in vitro
- From:
Chinese Traditional Patent Medicine
1992;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To prepare indirubin self-emulsifying drug delivery system(SEDDS) and evaluate it in vitro. METHODS: The criteria of SEDDS formation was studied and indirubin SEDDS preparation optimized with triangle phase diagram.In order to investigate self-emulsifying ability,the time of self-emulsifying,particle size of emulsion and the dissolution of indirubin in vitro were determined. RESULTS: The best formulation of SEDDS was made up of labrasol-peceol-transcutol P(85∶10∶5),which served as oil phase,emulsifier and assistant emulsifier,respectively.The selected formulation could completely emulsify in 5 min and the particle size was about 100 nm.As compared with indirubin suspension,SEDDS could improve drug dissolution significantly. CONCLUSION: SEDDS can give rise to the dissolution increase of slightly soluble drug in water in vitro.
