Aspero saponins phospholipid preparation and absorption in rats' intestine in situ
- VernacularTitle:续断总皂苷磷脂复合物制备工艺及大鼠在体肠吸收研究
- Author:
Yuzhi ZHANG
;
Zhonglin YANG
- Publication Type:Journal Article
- Keywords:
dipsacus total saponins;
phospholipid;
intestinal absorption;
HPLC
- From:
Chinese Traditional Patent Medicine
1992;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To prepare the asperosaponin—phospholipid compound to improve the bioavailability of asperosaponin in rat intestine in situ. METHODS: Ratio of asperosaponin to phospholipid was chosen as index to screen the optimal proportion based on the orthogonal design.Rat intestine perfusion was use to compare aspersaponin absorption under with and without phospholipid. RESULTS: Asperosaponin—phospholipid compound showed the markedly improvement in absorption capacity and absorption rate. CONCLUSION: The experiment recommends that asperosaponin in the combination with phospholipid is better than only used asperosaponin concerning bioavailability.
