Effect of Different Chinese Medical Therapies on Electrocardiogram and Endothelin in Rats with Acute Myocardial Ischemia

VernacularTitle:不同中医治法对急性心肌缺血大鼠心电图及内皮素的影响
Author: Youya LIANG ; Wanqing WU
Publication Type:Journal Article
Keywords: MYOCARDIAL ISCHEMIA/TCD therapy; XUEFU ZHUYU DECOCTION/pharmacology; GUALOU XIEBAI BANXIA DECOCTION/pharmacology; GUANXIN SUHEXIANG CAPSULES/pharmacology; ELECTROCARDIOGRAMDISEASE MODELS, ANIMAL; RATS
From: Journal of Guangzhou University of Traditional Chinese Medicine 2000;0(04):-
CountryChina
Language:Chinese
Abstract: Objective To observe the effect of therapies of activating blood and removing stasis, activating yang and dissipating phlegm, and warming and dredging meridians with aromatic herbs on relieving acute myocardial ischemia (AMI). Methods Rats were randomized into normal group,model group, Xuefu Zhuyu Decoction (XZD) groups (treated with XZD 20.5 and 6.8 gkg-1d-1 ), Gualou Xiebai Banxia Decoction (GXBD) groups (treated with GXBD 18.0 and 6.0gkg-1d-1 ), and Guanxin Suhexiang Capsules (GSC) groups (treated with GSC 0.19 and 0.06 gkg-1d-1 ). The AMI rat models were established by intravenous injection of pituitrin (Pit, 1.5U/kg) through the caudal vein. The effect of the three Chinese medical therapies on AMI rat electrocardiogram (ECG) and plasma endothelin (ET) level was evaluated. Results Compared with the model group, statistical significance was presented in the rise of ST segment of medication groups (P