Protective Effect of Jianpi Yangrong Tablets on Mice with Cyclophosphamide-induced Low Immunity
- VernacularTitle:健脾养荣片对环磷酰胺致免疫功能低下小鼠的保护作用
- Author:
Qingshou SHENG
;
Hui NONG
;
Riyong LUO
- Publication Type:Journal Article
- Keywords:
JIANPI YANGRONG TABLETS/pharmacology;
LEUKOPENIA/TCD therapy;
LEUKOPENIA/immunology;
DISEASE MODELS, ANIMAL;
MICE
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Jianpi Yangrong Tablets (JYT) on mice with cyclophosphamide-induced low immunity. Methods Sixty NIH mice were equally randomized into 6 groups: low-, middle-and high-dose JYT groups (4、8 and 16gkg-1d-1 respectively), batyl alcohol group (0.055gkg-1d-1), model group and normal group. The mice received gastric gavage of the corresponding drug according to the experimental design. On the 5th day of medication, the mice received intraperitoneal injection of cyclophosphamide 200mg/kg to induce the models of low immunity. On the 9th day of medication, peripheral white blood cell (WBC) count, carbon clearance test, bone marrow nucleated cells count, spleen index and proliferative reaction of spleen lymphocyteswere observed.Results The number of WBC in middle-and high-dose JYT groups and batyl alcohol group was higher than that in the model group (P
