Effect of Qidan Tongmai Tablet on Nitric Oxide Synthase of Ischemia/Reperfusion Myocardium in Rats
- VernacularTitle:芪丹通脉片对急性缺血/再灌注大鼠心肌一氧化氮合酶系统的影响
- Author:
Junchang LI
;
Wen WANG
;
Zongren WANG
- Publication Type:Journal Article
- Keywords:
Qidan Tongmai tablet;
ischemia/reperfusion injury;
myocardium;
NOS;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Qidan Tongmai tablet (QDTMT) on apoptosis and nitric oxide synthase (NOS) of ischemia/reperfusion myocardium in rats. Methods Male Sprague-Dawley (SD) rats were divided randomly into 4 groups:Sham, ischemia/reperfusion (control), QDTMT-Ⅰ (1.08 g/kg) treatment and QDTMT-Ⅱ (3.24 g/kg) treatment. Anesthetized and the open-chest animals were subjected to 40 min of myocardium ischemia followed by 4 h-reperfusion. The cardiomyocyte apoptosis was determined by terminal deoxynucleotidyl transfease-mediated dUTP nick-end labeling (TUNEL) method. The activity of NOS in heart tissue was assessed by chemical assay. Results Pretreatment with QDTMT at different doses reduced cardiomyocyte apoptosis indexes significantly compared with the control (P
