Effect of allopurinol on left ventricular remodeling and heart function in rats with myocardial infarction
- VernacularTitle:别嘌呤醇对心肌梗死后大鼠心室重构和心功能的影响
- Author:
Jun XIAO
- Publication Type:Journal Article
- Keywords:
Allopurinol;
Xanthine oxidase;
Reactive oxygen species;
Left ventricular remodeling;
Myocardial infarction
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of xanthine oxidase inhibitor allopurinol on left ventricular remodeling and function in rats with myocardial infarction(MI).Methods:MI models were produced by ligation of anterior descending coronary artery.The survivals were randomly divided into 3 groups:sham operation group,MI group and allopurinol group[50mg/(kg?d),n=15]. After 28 days,the parameters of echocardiogram and hemodynamics were investigated.The infarct size,LV weight index were detected,too.In addition,the activities of xanthine oxidase(XO) and ?O2-,?OH-scavenging were examined;the expression of XO was detected by Western blot.Results:Compared with sham group,the LV weight index and expression of XO were increased;the activity of XO was boosted but the heart function and activities of ?O2-,?OH-scavenging were decreased(P
