Anoxia-reoxygenation up-regulates transcription of TGF?_1 gene in human umbilical veins endothelial cell line
- VernacularTitle:缺氧再给氧上调人血管内皮细胞TGF?_1的基因转录
- Author:
Zhikang YIN
- Publication Type:Journal Article
- Keywords:
Anoxia-reoxygenation;
Human umbilical veins endothelial cell line;
Transforming growth factor-beta-1
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influence of anoxia-reoxygenation on the transcription of TGF?1 gene in Human umbilical veins endothelial cell line(ECV304). Methods:Anoxia-reoxygenation model of Human umbilical veins endothelial cell line was established. TGF?1 mRNA was half-quantitatively analyzed by a modified RT-PCR. Results:The transcription of TGF?1 mRNA was up-regulated significantly in anoxia-reoxygenation group compared with the control group. Conclusion: anoxia-reoxygenation may up-regulate the transcription of TGF?1 gene in human umbilical veins endothelial cell line.
