Study on injury in brain parenchyma surrounding intracebral hemorrhage induced by iron ions
- VernacularTitle:铁离子致脑出血后血肿周围组织损伤研究
- Author:
Shengshan LIU
- Publication Type:Journal Article
- Keywords:
Iron;
Intracerebral hemorrhage;
Deferoxamine
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the role of iron ions released by metabolism products of haemoglobin after intracerebral hemorrhage(ICH) in the injury of surrounding brain parenchyma and the influence of intervention by deferoxamine(DFO). Methods:Sprague-Dawley rats were randomly divided into the sham operation groups、intracebral hemorrhage(ICH) groups and deferoxamine groups,and received infusion of autologous blood. Evaluation on neurological function,brain water content,the permability of blood brain barrier,S100B proteins,neuron-specific-enolas(NSE) and the influence of intervention by deferoxamine were detected at different time points after operation. Results:Compared with the sham operation groups,the rats of ICH groups had significantly neurological disorder and the increase of brain water content surrounding brain parenchyma,the permeability of blood brain barrier,S100B protein and NSE of blood serum. The rats of DFO groups had the same trend with the rats of ICH groups in all kinds of observed items but neurological function scores test,brain water content surrounding brain parenchyma,the permeability blood brain barrier,S100B protein and NSE of blood serum were lower than those of ICH groups. Conclusion:The abnormal accumulation of iron ions participates the injury of brain tissue surrounding brain parenchyma after ICH and deferoxamine has the protective role for the injury.
