Oxidation and isomerous conversion of ?-asarone and borneol in Shenchang Injection
- VernacularTitle:神昌注射液中?-细辛醚、冰片的氧化及异构体转换分析
- Author:
Gang WEI
;
Jianxiong HE
- Publication Type:Journal Article
- Keywords:
Shenchang Injection;
?-asarone;
borneol;
isomerous conversion;
GC-MS
- From:
Chinese Traditional and Herbal Drugs
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze what will create after oxidation in Shenchang Injection, the oxidated mechanism, and isomerous conversion of ?-asarone and borneol in it. Methods To analyze the sample of Shenchang Injection before and after oxidation by GC-MS and to compare the composition of ?-asarone and borneol before and after sterilization. Results Some of ?-asarone was oxidized and changed to asarylaldehyde (about 0.88%—2.82% of total composition ) and saishinone (about 0.24%—0.46% of total composition), some of the borneol and isoborneol was oxidized and changed to camphor when three samples of Shenchang Injection are oxidized; some of ?-asarone (cis-) change to ?-asarone (trans-, about 1%—2%), (7.85?7.27)% of the isoborneol (cis-) changed to borneol (trans-) when sterilized at 100 ℃ for 30 min. Conclusion ?-Asarone and borneol in Shenchang Injection are involved in the oxidated reaction and have isomerous conversion after high pressure sterilization.
