Improving pancreas targeting capability of hydroxycamptothecin using lipid emulsion as drug carrier
- VernacularTitle:利用脂肪乳载体提高羟基喜树碱的胰腺靶向性
- Author:
Jianhua LIU
;
Ronggao JIANG
;
Chunlong WANG
- Publication Type:Journal Article
- Keywords:
camptothecin;
hydroxycamptothecin;
emulsion;
pancreatic gland;
HPLC
- From:
Chinese Traditional and Herbal Drugs
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of lipid emulsion as drug carrier on pancreas targeting capability of hydroxycamptothecin. Methods Hydroxycamptothecin-loaded lipid emulsion was prepared by a two-step emulsifying process with soybean phospholipid and soybean oil as main excipients. Hydroxycamptothecin-loaded lipid emulsion and hydroxycamtothecin injection were iv administrated to rabbits at a single dose of 3.5 mg/kg. The hydroxycamptothecin concentration in the pancreas was determined by HPLC with camptothecin as the internal standard. Results The HPLC method for the determination of hydroxycamptothecin and camptothecin was sensitive and accurate. The hydroxycamptothecin concentration in the pancreas was greatly improved in hydroxycamptothecin-loaded lipid emusion compared with hydroxycamtothecin injection. Conclusion The pancreatic gland targeting capability is greatly improved, when lipid emulsion is used as drug carrier.
