Expression and significance of CD8+CD28- T cells in the peripheral blood of patients with AS
- VernacularTitle:强直性脊柱炎患者外周血CD8+CD28-T细胞的表达及意义
- Author:
Haixia LI
;
Guirong SUN
;
Yongxian CAO
;
Jibo WANG
- Publication Type:Journal Article
- Keywords:
Spondylitis,ankylosing;
Antigens CD;
T lymphocytes
- From:
Chinese Journal of Rheumatology
2008;12(5):333-335,插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the expression of CD8+CD28- T cells in the peripheral blood and explore their roles in the pathogenesis of AS. Methods The expression of CD8+CD28- T cells obtained from 50 AS patients and 21 healthy controls were assayed by flow cytometry. CRP was also measured. Results The percentage of peripheral blood CD8+CD28- T cells in patients with AS was significantly increased compared to normal individuals [(18±6)% vs (14±5)%, P=0.020], while the percentage of peripheral blood CD3+,CD8+ CD28+ T cells in patients with AS was significantly decreased[ (65±9)% vs (69±8)%, P=0.039]; [ (15±5)% vs(18±4)%, P=0.038]. No difference was found in CD8+ T cells between patients with AS and normal individuals(P＞0.05). Conclusion The percentage of peripheral blood CD8+CD28- T cells in patients with AS is significantly increased comparing to normal individuals. This suggests that CD8+CD28- T cells may play an important role in the pathogenesis of AS.
