Establishment and evaluation of VX2 lung cancer model(squamous cancer) in rabbits
- VernacularTitle:兔VX2肺癌(鳞癌)模型的建立及鉴定
- Author:
Huijun ZHANG
- Publication Type:Journal Article
- Keywords:
VX2;
Lung cancer;
Model
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the establishment method and bionomics of VX2 lung cancer models in rabbits.Methods: VX2 tumor fragments,preserved from autoinculation rabbits into the lungs of healthy rabbits to establish the models,and then the tumorous growth was observed through the imageology and the morphology of the samples including the lung,the cardia,the liver,the kidney,the brain and lymphatic gland after death at different time.Results:(1) the achievement ratio of modeling was 100%。(2)The VX2 tumor discovered evidently in lung were displayed for diffuse,inequality of size,tuberculum and fish surface.It was visible that metastatic tumor,which were invasion,were discovered evidently in all six organs except for the brain after vaccination for six days.(3)Squamous cell carcinoma,which was originated from epithelial tissue,was confirmed through pathologic histology and immunohistochemistey.Conclusions:The construction of VX2 tumor animal models in rabbits by applying organism fragments not only is simple in method,free from infection and high in achievement ratio but also the biological behaviour of VX2 is similar to human tumors,with high level of malignancy.This study provides valuable guidance for the construction of the large animal models of the lung cancer.
