The expression of RGMa and RhoA in the hippocampus of rats with cognitive impairment induced by A?
- VernacularTitle:A?诱导的认知障碍大鼠海马RGMa和RhoA表达的研究
- Author:
Honglei YIN
- Publication Type:Journal Article
- Keywords:
Repulsive guidance molecule;
Ras homologous;
?-amylod protein;
Hippocampal neuron;
Cognitive handicap
- From:
Journal of Chongqing Medical University
2008;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the expression of RGMa and RhoA in the hippocampus of cognitive impairment rats induced by A?1-40. Methods:Morris water maze was used to study the cognitive function, and reverse transcription-polymerase chain reaction(RT-PCR)method was used to determine the changes of RGMa mRNA and RhoA mRNA expressions. mmunohistochemistry was used to detect the expression of RGMa protein. Results:Model group showed learning and memory impairment, the expression levels of RGMa mRNA and protein in the hippocampus decreased compared with control group(p
