Effect of fastigial nucleus stimulation on GFAP expression in hippocampus with Alzheimer disease in rats
- VernacularTitle:电刺激小脑顶核对老年痴呆大鼠海马胶质纤维酸蛋白的表达影响
- Author:
Jing LUO
- Publication Type:Journal Article
- Keywords:
Amyloid beta-protein;
Astrocyte;
Glial fibrillary acidic protein
- From:
Journal of Chongqing Medical University
2008;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Observe the effects of fastigial nucleus stimulation(FNS) on spatial memory and learning ability of the A?1-40 induced Alzheimer rat model,by detecting GFAP expression of hippocampus area. Methods:A?1-40 was microinjected into the right hippocampus of rats. Cerebella dentate nucleus and fastigial nucleus were stimulated separately before the model was made in interference group. The spatial memory and learning ability of the rat was evaluated by the Morris water maze procedure at the 28th days after injection. The expression of GFAP in astrocyte cell was determined with immunohistochemistry method.Results:The AD rats received FNS showed significant shorter escape latency than the group without FNS(P
