Membrane formulation optimization of osmotically controlled release tablets of colchicine with uniform design
- VernacularTitle:均匀设计法优化秋水仙碱渗透泵控释片的衣膜处方
- Author:
Wenping WANG
- Publication Type:Journal Article
- Keywords:
colchicine;
uniform design;
osmotic pump;
controlled release tablets
- From:
Chinese Traditional Patent Medicine
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To prepare controlled release tablets of colchicine and establish the relationship among formula factors of membrane and drug release rate. METHODS: Uniform design was used to achieve the quantitative relationship among the release rate of colchicine,acetyl cellulose and PEG 6000.Optimized prescriptions were calculated from the regression equation. RESULTS: A significant correlation and a fine precision were obtained.(Osmotically) controlled release tablets of colchicine were prepared based on the calculations,and the drug release pattern was in accordance with zero-order kinetics(r=0.990 2). CONCLUSION: Uniform design is a convenient and efficient approach to the formulation optimization of elementary osmotic-pump tablets.
