Effect of Yiru Granule on apoptotic expressions (Bcl-2/Bax) in endometriotic and ovary cell of the hyperprolactinemia models rat
- VernacularTitle:抑乳颗粒对高泌乳素血症大鼠子宫卵巢bcl-2/bax的影响
- Author:
Lei XIA
;
Hairong ZHANG
- Publication Type:Journal Article
- Keywords:
hyperprolactinemia;
bcl-2;
bax;
prolactin;
Yiru Granule
- From:
Chinese Traditional Patent Medicine
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effect of Yiru Granule on the female rat of hyperprolactinemia models. METHODS: Subcutaneous injection of maxolon was applied to establishing the mice model with hyperprolactinemia.Rats were at random divided into five groups,model control group,bromocriptine group,Yiru Granule of high dose,middle dose and low dose,and one normal group.The treatment lasted 30 days,serum levels of PRL,T,FSH, LH,P and E_2 were measured.Finally,the apoptosis regulatory protein bcl-2 and bax were assayed through immunohistochemical method and we used picture-analysing instrument to dispose the data. RESULTS: The middle and high dosage of Yiru Granule could not only inhibit the level of prolactin of the hyperprolactinimia rat models,but also increase the levels of estrogen and progesterone(P
