Study on Different Expression of Genes Associated with Inflammatory and Immune Response in Rats with Qi Deficency and Blood Stasis Syndrome
- VernacularTitle:气虚血瘀大鼠炎症免疫相关基因差异表达的研究
- Author:
Ya LIU
;
Shuhui LI
;
Xiaohui LI
- Publication Type:Journal Article
- Keywords:
Qi deficency and blood stasis syndrome;
animal model;
gene chip;
inflammation;
immune response
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate molecular biological basis associated with inflammatory and immune response in Qi deficency and blood stasis syndrome. Methods Twelve rats were randomly divided into model group and control group. Rat Genome 230 2.0 Array Gene Chip was used for examination of gene expression profiles in rats with Qi deficiency and blood stasis syndrome and normal rats. Differental expression genes associated with inflammatory and immune mechanism were analyzed. Results Compared with the control group, there were different expression genes in model group, the up-regulated were 831 genes, known functional genes 563, and down-regulated 782, known functional genes 544. The expression level increased in 50 genes and decreased in 17 genes associated with inflammatory and immune response. Conclusion Differental expression genes associated with inflammatory and immune response revealed that there was close correlation between Qi deficency and blood stasis syndrome and abnormal inflammatory and immune response.
