Effects of ligustrazine on adhesion,migration and invasion of Jurkat cells
- VernacularTitle:川芎嗪对白血病细胞Jurkat粘附、运动和侵袭的影响
- Author:
Wei ZHANG
- Publication Type:Journal Article
- Keywords:
Ligustrazine;
Leukemia;
Cell;
Adhesion;
Migration;
Invasion
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the inhibitory effects of ligustrazine on adhesion,migration and invasion of human acute lymphoblastic leukemia(ALL) cell line Jurkat.Methods:Jurkat cells were cultured in vitro and treated by 50?g/ml,100?g/ml and 150?g/ml ligustrazine respectively.Then the adhesion,migration and invasion of Jurkat cells were measured with cell adhesion test,cell migration test and cell invasion test.The measurement data was collected and the multi-samples were analyzed by analysis of variance(One-Way ANOVA).Results:Compared with control group,50?g/ml,100?g/ml and 150?g/ml ligustrazine could significantly inhibit the migration of Jurkat cells and their invasion to basement membrane(P0.05).Conclusion:By roundly inhibiting adhesion,migration and invasion of Jurkat cells,ligustrazine is a good inhibitor to leukemia and the inhibitory effects are dose dependent.
