Effect of GETO on Learning and Memory of Sporadic Alzheimer’s Disease Rats
- VernacularTitle:金思维对散发性老年性痴呆模型大鼠学习记忆能力的影响
- Author:
Yujing CHEN
;
Jinzhou TIAN
;
Rong WANG
- Publication Type:Journal Article
- Keywords:
GETO;
Alzheimer’s Disease;
insulin;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish rat models with Sporadic Alzheimer’s disease(SAD) induced by intracerebroventricular administration of streptozotocin(ic-STZ),and observe the effects of compound Jinsiwei(GETO) on learning and memorizing ability of rats.Methods To establish the Sporadic Alzheimer’s disease model by intracerebroventricular micro-injection of STZ bilaterally.GETO groups were treated with gastric perfusion of GETO in three different dosage for 3 months.Learning and memorizing ability of the rats were inspected through Morris water maze test.The effects of GETO and Donepezil were observed and compared.Results In place navigation test,the escape latency and swimming distance were significantly longer in the model group than that in the sham group(P
