Experimental Study of Xiaomin Granules on Antagonizing Type Ⅰ Hypersensitivity
- VernacularTitle:消敏颗粒抗皮肤Ⅰ型超敏反应的实验研究
- Author:
Xinhong LI
;
Xing CHEN
;
Hongquan GUAN
- Publication Type:Journal Article
- Keywords:
Xiaomin granules;
type Ⅰ hypersensitivity;
mice
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects and mechanism of Xiaomin granules on type Ⅰ hypersensitivity.Methods The experimental animal model was made for type Ⅰ hypersensitivity.The mice were divided into five groups named vacant control group,Xiaomin granules(low-,middle-and high-dose) group,chlorpheniramine group randomly and were given homologous medication respectively.Results Xiaomin granules can inhibit capillary penetrance caused by histamine and 5-HT in mice(P 0.05).Xiaomin granules could inhibit the mice hind paw edema degree caused by histamine.The further study found that Xiaomin granules could decrease anaphylactic shock of the mice and decrease the death rate.Conclusions Xiaomin granules could restrain type Ⅰ hypersensitivity by inhibiting inflammatory mediators.
