Effect of Danxuan Koukang on Proliferation and PCNA Production of Human Oral Mucosal Fibroblasts Induced by Areca Nut Extract
- VernacularTitle:丹玄口康对槟榔提取液刺激下的人口腔黏膜成纤维细胞增殖及增殖细胞核抗原表达的影响
- Author:
Yuancong LI
;
Jin TAN
;
An CHEN
- Publication Type:Journal Article
- Keywords:
Danxuan Koukang;
areca nut extract;
fibroblasts;
proliferating cell nuclear antigen
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Danxuan Koukang(DXKK) drug serum on proliferation and proliferating cell nuclear antigen(PCNA) production of human oral mucosal fibroblasts(FB) induced by areca nut extract(ANE).Methods Human oral mucosal FB were cultured in vitro,100 ?g/mL ANE was used as inducement and 10% DXKK drug serum as intervenor.The cell proliferation rates were measured by MTT assay,PCNA productions were examined by immunocytechemistry.Results MTT assay showed OD value in DXKK groups were significantly decreased compared with the induced group(P
