EFFECT OF OVARIECTOMY ON THE EXPRESSION OF ESTROGEN RECEPTER SUBTYPE IN THE ADRENAL GLANDS OF THE RATS
- VernacularTitle:卵巢切除对大鼠肾上腺雌激素受体亚型表达的影响
- Author:
Xiaoou XUE
- Publication Type:Journal Article
- Keywords:
Ovariectomy;
Adrenal gland;
Estrogen receptor;
Immunohistochemistry;
Rat
- From:
Acta Anatomica Sinica
1954;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The mechanism of the influence on adrenal glands of the ovariectomy rats was studied by observing the expression of estrogen receptor subtype in adrenal glands of the rats. Methods Twenty adult female Wistar rats were divided into 2 groups:the sham-operated group(10 rats) and the model group(10 rats).After 6 weeks all rats were killed and the adrenal glands were excised,and the tissues in each group were studied with the method of immunohistochemistry.The level of estrogen(E2) and follicle stimulating hormone(FSH) in blood serum was measured by radiation immunohistology. Results 1.Staining for ER? and ER? were the densest in zona fasciculats and zona reticularis with lesser staining in the zona glomerulosa.ER? expressed weaker than ER?.2.ER? expressed in the sham-operated groups and less intensity than in the model groups,it had statistically significant.3.The level of FSH in the serum of the ovariectomy rats was increasing and the E2 was decreasing,there was great difference between the sham-operated groups and the model group.Conclusion The expression of either ER? or ER? on the rat adrenal gland was obviously influenced by ovariectomy,especially the expression of ER?.Ovariectomy could decrease E2 in serum and increase FSH which excretes from pituitary through feedback.
