Effect of angelica polysaccharides on adhesion molecules expressions in murine hematopoietic cells
- VernacularTitle:当归多糖对小鼠造血细胞表面粘附分子表达的影响
- Author:
Xiaoli DU
- Publication Type:Journal Article
- Keywords:
Angelica polysaccharides;
Hematopoietic stem and progenitor cells;
Adhesion molecule;
VLA-4;
CD44
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of angelica polysaccharide(APS)on adhesion molecules expressions in murine hematopoietic cells,in order to provide experimental evidence of APS on hematopoietic regulation and the mechanism of mobilizing.Methods:Techniques of peripheral blood white blood cell(WBC)and bone marrow mononuclear cells(MNC)count were made.Flow cytometry detected the rate of Sca-1~+ cells in peripheral blood and bone marrow and the expression of CD49d (VLA-4 of a chain),CD44 on bone marrow MNC and Sca-1~+ cells.Results:1.In APS group(4mg/kg):the number of peripheral blood WBC and Sca-1~+ cells were markedly higher than that of NS group(P
