Effect of sonodynamic therapy with hematoporphrin on the expression of VEGF in chick chorioallantoic membrane
- VernacularTitle:超声激活血卟啉声动力作用对鸡胚绒毛尿囊膜VEGF表达的影响
- Author:
Jing WANG
- Publication Type:Journal Article
- Keywords:
Sonodynamie effect;
Hematoporphrin;
Chorioallantoie membrane;
Angiogenesis;
VEGF
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of sonodynamic therapy with hematoporphrin on the expression of VEGF in Chick Chorioallantoic Membrane and provide experimental basis for appling sonodynamic therapy(SDT)on anti-angiogenesis in tumor therapy.Methods:The hatching eggs cultured for 7 days were randomly divided into 4 groups:blank control group,ultrasound group,hematoporphrin group,sonodynamic therapy group.The express of VEGF in CAM was detected by immunity histochemistry.Result:There were significant differences between control group and ultrasound group(P0.05),conclusion The results show that sonodynamic therapy with hematoporphrin has a significant inhibitionary effect on the express of VEGF in CAM and this maybe is the most important mechanism of its anti-angiogenesis effect.
