Study on the In- vitro Recovery of Tetramethylpyrazine Phosphate in Microdialysis Probe
- VernacularTitle:磷酸川芎嗪微透析体外回收率的研究
- Author:
Yilin YAN
;
Yong YE
;
Liling ZHOU
;
Xiaoshan LIN
- Publication Type:Journal Article
- Keywords:
Tetramethylpyrazine phosphate(TMPP);
Microdialysis;
Recovery
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the in-vitro recovery of tetramethylpyrazine phosphate (TMPP) in microdialysis probe and to study its stability. Methods The recovery of TMPP was detected by concentration difference method (increment method and decrement method ). The effect of flow rates and concentrations on recovery was studied. Results The recovery detected by increment method was as the same as that detected by decrement method; TMPP recovery was independent of TMPP concentration in the external medium. TMPP recovery had good stability. Conclusion Microdialysis sampling can be used for the pharmacokinetic study of TMPP and decrement method (ie. retrodialysis) can be used for the determination of TMPP recovery.
