Effect of Curcumine on Expression of Matrix Metalloproteinase- 9 in Human Umbilical Vein Endothelial Cell
- VernacularTitle:姜黄素对人脐静脉内皮细胞基质金属蛋白酶-9的影响
- Author:
Yun ZHANG
;
Zongren WANG
;
Manli LIU
- Publication Type:Journal Article
- Keywords:
Curcumine;
Human umbilical vein endothelial cell;
Matrix metalloproteinase- 9
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of curcumine on the expression of matrix metalloproteinase-9 (MMP-9) in human umbilical vein endothelial cell (HUVEC). Methods HUVEC were cultured and identified in vitro .After cultured with curcumine at different concentration for 24 hours, the expression of MMP-9 in HUVEC was detected by cytoimmunochemical staining method and ELISA . Results All concentrations of curcumine can restrain the expression of HUVEC after co- culturing with the cells for 24 hours. The inhibitory effect got stronger with the increase of the concentration of curcumine. Conclusion The curcumine can depress the expression of matrix metalloproteinase-9 in HUVEC obviously.
