Absorptive property of eleutheroside B in rat intestine
- VernacularTitle:刺五加苷B的大鼠在体肠吸收特性研究
- Author:
Xiaobin TAN
- Publication Type:Journal Article
- Keywords:
eleutheroside B;
absorption;
metabolism;
entero-enzyme;
in situ perfusion;
HPLC
- From:
Chinese Traditional Patent Medicine
1992;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe the absorption characteristics,absorption sites,and mechanism of eleutheroside B from Radix acathopanacis senticosi in various intestinal segments in rat and provide theoretical evidences for designing its preparation. METHODS: In situ perfusion method in rats.The absorption characteristics and absorption sites of eleutheroside B in intestine were applied. RESULTS: Absorbed dose and intestinal surface permeation rate of various intestinal segments decreased in turns in duodenum,jejunum,ileum,and colon;The concentration of eleutheroside B degraded through intestinal enzyme declined in turns in same manner. CONCLUSION: The poor bioavailability of eleutheroside B is not only due to absorption but also due to enzymolysis.
