Paeonia glycoside extracts coated sustained release pellets in vitro
- VernacularTitle:白芍总苷缓释微丸体外释放评价方法的研究
- Author:
Junsong LI
;
Yi FENG
- Publication Type:Journal Article
- Keywords:
sustained preparation;
paeonia glycosides;
HPLC fingerprint;
in vitro
- From:
Chinese Traditional Patent Medicine
1992;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To explain the drug-release behavior of paeoniflorin from paeonia glycosides sustained-releasing pellets according to different coating material. METHODS: HPLC method was used to gain the fingerprint of pellets,paeoniflorin was sellected as marker to calculate the linear equation concerning peak area,and acquire relative drug-release. RESULTS: The releasing process of paeoniflorin and other constituents from paeonia glycosides fit in with peppas and Huguchi equation. CONCLUSION: The chromatographic peaks stand for paeonia glycosides can well elucidate the releasing behavior in vitro of paeonia glycosides sustained-releasing pellet.
