Effect of Shen-fu injection on pulmonary contusion rabbits

VernacularTitle:参附注射液对兔肺挫伤治疗作用的实验研究
Author: Hongjun ZHU ; Shudong YU ; Jingkang HE ; Shiqi LU
Publication Type:Journal Article
Keywords: Pulmonary contusion; Shen-fu injection
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(9):1542-1543,插1
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of Shen-fu injection on pulmonary contusion rabbits. Meth-ods Sixteen rabbits were randomly divided into 2 groups: the treatment group (Shen-fu group) and the control group. The animals were induced the pulmonary contusion models. After 60min, the animals in Shen-fu group re-ceived Shen-fu injection received 5 ml/kg, and those in control group 5 ml/kg LRS. The animals were killed six hours later, the right lung tissue wet-to-dry (W/D) ratio and myeloperoxidase (MPO) activity were obtained,the pro-tein expression of nuclear factor-kappa B (NF-κB) and intercellular adhesion molecule-1 (ICAM-1) were also detec-ted. Results The lung tissue W/D, MPO, and the protein expression of NF-κB and ICAM-1 were decreased evi-dently in Shen-fu group (P<0. 01). The morphologic and ultrastructural damages in Shen-fu group were milder than in control group. Conclusion Shen-fu injection is effective on pulmonary contusion rabbits.