Characteristic pattern of neuron firings at hippocampus CA1 for fast-aging mouse
10.3760/cma.j.issn.1673-4181.2010.01.006
- VernacularTitle:快速老化小鼠海马脑片CA1区神经元放电特征模式研究
- Author:
Xiaobo ZHENG
;
Tiaotiao LIU
;
Xin TIAN
- Publication Type:Journal Article
- Keywords:
Fast aging;
SAM-P/8 mouse;
Hippocampus slice;
CA1;
Firing-rate
- From:
International Journal of Biomedical Engineering
2010;33(1):24-26,30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of fast-aging on the excitability of hippocampus CA1 neurons in mouse and the possible interaction between fast-aging and hippocampus. Methods Using brain slice and extracellular recording technique to record the firing of hippocampus CA1 neurons in fast-aging(SA M-P/8) and normal control mice, after preprocessing, neural firing train were obtained. Using neural firing rate and inter-spike-inter to investigate interaction between fast-aging and hippocampal neural firing. Results The neural firing rate of hippocampus CA1 neurons in fast-aging mice is (1.052±0.364) Hz(n=14), while the neural firing ratein normal control mice is (4.416±1.306) Hz(n=22). In fast-aging mice, 80.5% inter spike intervel(ISI) is longerthan 1sec, but in normal control mice, 95.6% ISI is shorter than 0.5sec. Conclusion The decreased firing rate of hippocampus CA1 and longer ISI observed in the fast-aging mice indicates that fast-aging significantly inhibit hippocampal CA1 neurons excitability.
