Experimental Study on the Anti-inflammation Effect of 3,4-oxo-isopropylidene-shikimic Acid
- VernacularTitle:异亚丙基莽草酸抗炎作用机制研究
- Author:
Xiaojun CHEN
;
Ligang GU
;
Taiping SHI
- Publication Type:Journal Article
- Keywords:
3,4-oxo-isopropylidene-shikimic acid;
NF-?B;
anti-inflammation;
Hela cell
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of 3,4-oxo-isopropylidene-shikimic acid (ISA) on transcription factor STAT1, STAT3 and NF-?B in human cervix cancer Hela cell. Methods The cell proliferation was assessed by MTT assay. The luciferase activity of transcription factor STAT1, STAT3 and NF-?B was determined by the Dual-Luciferase Reporter Assay System. Results ISA can not inhibited the growth of Hela cell. The luciferase activity of transcription factor NF-?B in Hela cells treated with ISA was inhibited, while the luciferase activities of transcription factor STAT1 and STAT3 were not inhibited. Conclusion ISA can inhibit inflammation, which may be related with suppression of NF-?B transcriptional activity.
