Effect of Myospalax fontanieri bone extracts on the function of CFA induced mice
- VernacularTitle:塞隆骨提取物对CFA诱导活化的小鼠腹腔巨噬细胞功能的影响
- Author:
Xiaohui ZHAO
- Publication Type:Journal Article
- Keywords:
macrophages;
ELISA;
complete Freund's adjuvant
- From:
Chinese Traditional Patent Medicine
1992;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
AIM:To investigate the mechanisms of Myospalax fontanieri bone extracts for macrophages activation. METHODS: Complete Freund's adjuvant was used to induce mouse celiac macrophage activation by ip,then peritoneal exudate cells were cultured in vitro in the present of LPS and IFN-?,concentrations of IL-1?,IL-6,IL-12p40,and TNF-? were by ELISA measurement and the MAC-1 cell proportion was determined by FACS Calibur. RESULTS: Myospalax fontanieri bone had immunosuppressive effect on mouse celiac macrophages,and markedly decreased production of inflammatory Cytokine. CONCLUSION: Inhibition of inflammatory factor may be the mechanism of action for rheumatoid arthritis.
