Study of the PHB/PEO polymer combined with nerve growth factorin sciatic nerve injury
- VernacularTitle:PHB/PEO共聚物复合神经生长因子治疗坐骨神经损伤研究
- Author:
Yu CHEN
- Publication Type:Journal Article
- Keywords:
PHB/PEO polymer;
Peripheral nerve;
Injury
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of PHB/PEO polymer combined with nerve growth factor in the peripheral nerve injury.Method:The male SD rats were treated with autogentic neural transplantation,xenogenic neural transplantation under the immunosuppression,transplantation of PHB/PEO polymer combined with nerve growth factor and PHB/PEO guidance transplantation,respectively.The nerve function and the nerve anatomic structure were evaluated by the sciatic function index(SFI),nerval electrophysiology test,nerve fiber number and electron microscope.Result:The SFI,nerve conduction velocity,nerve fiber number and the regeneration of nerve fiber and myeline sheath of the PHB/PEO polymer combined with nerve growth factor group is similar to the autogentic neural transplantation group,and is better than the xenogenic neural transplantation group and PHB/PEO guidance group significantly.Conclusion:The effect of PHB/PEO polymer combined with nerve growth factor is similar to the autogentic neural transplantation,and is better than the xenogenic neural transplantation and PHB/PEO guidance significantly in the repair of sciatic nerve injury.
