Effects of RPM on renal function and ultrastructure after ischemia-reperfusion in rats
- VernacularTitle:雷帕霉素对肾缺血再灌注大鼠肾功和肾组织超微结构的影响
- Author:
Chuandong ZHENG
- Publication Type:Journal Article
- Keywords:
Reperfusion injury;
Uhrastructure;
Rapamycin(RPM)
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of rapamycin on renal function and ultrastructure changes after renal ischemia-reperfusion in rats.Methods:Acute ischemic renal injury model was established(right kidney ectomized,45 min of left renal ischemia and reperfusion for 24h).Thirty male Wistar rats were randomly divided into 3 groups:sham operation group(control group or group C,without renal ischemia),renal ischemia-reperfusion group(ischemia-reperfusion group or group I,without rapamycin),renal ischemia-reperfusion and(RPM 4mg/(kg?d)?3d,reperfusion at 2h before the last operation) intravenous injection group(rapamycin group or group U).changes of renal function and renal uhrastructure were measured BUN level,serum creatinine values.Results:Serum creatinine(168?37)?mol/L and BUN concentration(22?6)mmol/L in group I were significantly higher than those in group U:serum creatinine(113?17)?mol/L and BUN concentration(13.8?2.3)mmol/L(P
