Influence of material and configuration of microfiltration membranes on preparation of mono-ammonium glycyrrhizinate liposome by membrane extrusion method
- VernacularTitle:微滤膜材料与结构对甘草酸单铵脂质体膜挤压滤过工艺的影响
- Author:
Taoshi LIU
;
Xinhui ZHAO
;
Jinao DUAN
;
Liuqing DI
;
Jianming CHENG
;
Yaozhou HUANG
- Publication Type:Journal Article
- Keywords:
liposome;
microfiltration membranes;
mono-ammonium glycyrrhizinate
- From:
Chinese Traditional Patent Medicine
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the influence of material and configuration of microfiltration membranes on preparation of mono-ammonium glycyrrhizinate liposome(MGL) by membrane extrusion. METHODS: MGL were preparated by conventional rotary-evaporated film dispersion method and sonication,and MGL were extruding through 9 kinds of microfiltration membranes with 3 kinds of aperture specs of 0.1,0.2,0.45 ?m.The methods were evaluated by the filtration efficiency and the leakage rate of drug from liposomes. RESULTS: MGL were easily extruding through microfiltration membranes of NY6,PTFE,PVDF,PP and PC.MGL could not extruding through microfiltration membranes of PES,CN,CA and CA-CN.MGL become hardly to extrude through microfiltration membranes when increasing in the concentration of liposomes or the content of cholesterol.The leakage rate of drug from MGL was small when extruding through microfiltration membranes. CONCLUSION: The material and configuration of microfiltration membranes can remarkably influence the preparation of MGL by membrane extrusion method,and PC microfiltration membrane was selected.
