Effects of Volatile Oil of Rhizoma Zingiberis and Other 2 Kinds of Volatile Oil on Percutaneous Penetration of Total Alkali of Shortstalk Monkshood Root
- VernacularTitle:石菖蒲、肉豆蔻、橘皮挥发油对雪上一枝蒿总碱经皮渗透的影响
- Author:
Yicen BAI
;
Yanjie LI
;
Yunshu MA
- Publication Type:Journal Article
- Keywords:
penetration enhancers;
Shortstalk Monkshood Root;
volatile oil of Rhizoma Acori Tatarinowii;
volatile oil of Semen Myristicae;
volatile oil of Pericarpium Citri Reticulat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of volatile oils of Rhizoma Acori Tatarinowii (RAT), Semen Myristicae (SM) and Pericarpium Citri Reticulatae (PCR) on percutaneous penetration of total alkali of Shortstalk Monkshood Root through mouse skin in vitro. Methods By using an improved Franz diffusion cells, the effects of these 3 kinds of volatile oil on the percutaneous penetration of total alkali of Shortstalk Monkshood Root were observed and compared with Azone, and the cumulative amount of Bullatine A was determined by HPLC. Results 7% (v/v) volatile oil RTA and SM, 5% (v/v) volatile oil of PCR and 3% (v/v) Azone were best concentration, the penetration coefficient were 5.88, 6.91, 5.30, 5.75, respectively. Compared with the group without penetration enhencers, the enhancement ratios were 1.09,1.28, 0.98, 1.06, respectively. Conclusion The volatile oil of RAT and SM enhance penetration of total alkali of Shortstalk Monkshood Root. The volatile oil of PCR cannot enhance penetration.
