Effect Evaluation and Mechanism Study of Gastrodin against Migraine of Rat
- VernacularTitle:天麻素预防大鼠偏头痛发作的功效评价及其作用机制研究
- Author:
Huilan LIU
;
Kegang CAO
;
Yonghong GAO
- Publication Type:Journal Article
- Keywords:
gastrodin;
migraine;
neurotransmitter;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the effects and mechanism of gastrodin against migraine and on single amine neurotransmitter. Methods The model of nitroglycerin migraine was made after rat treated by gastrodin for 5 days, the time points of ear rubescence and the times of scratch head were observed to take as evaluation index of pharmacodynamic action, the concentration of 5-HT, NE and DA were measured in the brain with HPLC. Results Gastrodin could obviously prevent the attack of migraine and increase the concentration of 5-HT, DA and NE in the brain. Conclusions The effects of gastrodin against migraine is related with the concentration of 5-HT, DA and NE in the brain, gastrodin can regulate neurosystematic functions and enhance the secretion and metabolism of neurotransmitters.
