Preparation of floating rutin-alginate-chitosan microcapsule
- VernacularTitle:芦丁壳聚糖-海藻酸钠漂浮微囊的制备研究
- Author:
Li XIAO
;
Yunhui ZHANG
;
Jianchen XU
;
Xinghua JIN
- Publication Type:Journal Article
- Keywords:
rutin;
floating alginate-chitosan microcapsule;
pulsatile drug delivery system
- From:
Chinese Traditional and Herbal Drugs
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Using rutin as the model drug to prepare floating alginate-chitosan microcapsule and investigate the feasibility of this pulsatile drug delivery system applied in Chinese materia medica.Methods By means of complex coacervation to prepare alginate-chitosan microcapsule and foaming agent to turn the microcapsule into gastric floating system and to investigate the release profile of the microcapsule in vitro and the influence of gas forming agent to the lag-time of the microcapsule.Results In vitro release,the microcapsule responded to the change of pH value and the release profile showed "S" profile,the lag-time increased from 3 h to 6 h as the quantity of gas forming agent with the dosage of foamer increased.Conclusion Floating alginate-chitosan microcapsule is suitable to be applied in pulsatile drug delivery system of Chinese materia medica with the desirable entrapment efficiency.
