THE STUDY ON THE EXPRESSION OF BASIC FIBROBLAST GROWTH FACTOR AND TRANSFORMING GROWTH FACTOR-BETA IN THE SCLERA OF HUMAN FETUS
- VernacularTitle:胎儿巩膜碱性成纤维细胞生长因子和转化生长因子?表达的研究
- Author:
Ying XIAO
- Publication Type:Journal Article
- Keywords:
bFGF;
TGF-?;
Posterior sclera;
Real-time PCR;
Human fetus
- From:
Acta Anatomica Sinica
1953;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
Objective To evaluate the existence of basic fibroblast growth factor(bFGF) and transforming growth factor-beta(TGF-?)in the sclera in different fetal ages by real-time polymerase chain reaction(PCR). Methods Forty human fetal eyes ranging in age from 12 to 20 pregnant weeks were carefully extracted.The sclera was carefully dissected.The expressions of bFGFand TGF-? were determined by real-time PCR,and the results were analyzed comparatively. Results bFGF was expressed in the highest amount at the 12th to 14th pregnant week and decreased thereafter,while the expression of TGF-? lowered at the 12th week and increased gradually.Conclusion bFGF and TGF-? express in the sclera of the human fetal eyes during the whole period of the fetal development and changed with fetal ages.
