Optimization of Solid Dispersion Prescription of the Extract of Fructus Cnidii
- VernacularTitle:蛇床子提取物固体分散体处方优选
- Author:
Zhenhua WANG
;
Jiu WANG
;
Linli CHEN
;
Weimin LI
- Publication Type:Journal Article
- Keywords:
Osthol;
Solid dispersion;
Uniform design;
Releases rate
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To obtain the optimal solid dispersion prescription of the extract of Fructus Cnidii.Methods The release rate t63.2 was used as index and uniform design was used to investigate the effect of PEG,PVP,and Poloxamer on the release of the solid dispersion of the extract of Fructus Cnidii.Results PVP,PEG can delay the release of osthole from the solid dispersion,and tween-80 can promote its release.Conclusion The optimal solid dispersion prescription consists of tween-80(10.2 %),Poloxamer(79.8 %) and the extract(10 %).
