Therapeutic Effects of Methyl Protodioscin for Myocardial Infarction in Rats
- VernacularTitle:薯蓣皂苷元对大鼠急性心肌缺血的治疗作用
- Author:
Keyong NING
;
Yikui LI
;
Huili GAO
;
Lianda LI
- Publication Type:Journal Article
- Keywords:
Methyl protodioscin;
Myocardial infarction;
Rats
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the therapeutic effects of methyl protodioscin (MPD ) on myocardial infarction in rats. Methods Rat models of myocardial infarction were induced by ligation of coranary artery. Then myocardium infarction area and the vasoactive substance were measured to evaluate the therapeutic effect of MPD on acute myocardial infarction in rats. Results Compared with the control group,MPD lessened the myocardial infarction size dramatically,inhibited the increase of CK and LDH ,lowered the increased MDA content level and improved the activity of SOD and NO. Conclusion MPD reduces the level of myocardium enzyme and the myocardial infarction size,and increases the capability of clearing oxygen free radical and function of the vascular endothelial cell. MPD by intravenous injection has a better effect than that by oral use.
