Correlation between drug effects and serum HPLC fingerprint of active compositions of Radix paeoniae alba and Radix et Rhizowa Glycyrrhizae
- VernacularTitle:芍药甘草效应组分血清指纹图谱与药效的相关性研究
- Author:
Ying GU
;
Yi FENG
- Publication Type:Journal Article
- Keywords:
active compositions of paeoniflorin and Ghycyrrhizic;
serum HPLC fingerprint;
correlation;
mouse
- From:
Chinese Traditional Patent Medicine
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the correlation between the drug effects and serum HPLC fingerprint from active compositions of Radix paeoniae alba and Radix et Rhizowa Glycyrrhizae. METHODS: Orthogonal design of L_9(3~4) of the different combinations of three active compositions of paeoniflorin,glycyrrhiza flavoues and Glycyrrhizic acid were prepared,antalgic pharmacological experiments of mice were carried out.The fingerprints of the serum were tested by HPLC method and different chromatographic peaks were obtained.Correlation analysis was applied to interelationship between the area of each peaks and the pharmacologic data. RESULTS: Correlation coefficients were different between pear areas and analgetic coffec. CONCLUSION: This study provides a significant try of investigating the compatibility of composite herbal medicines.
