Experimental research of Jiajian Yun? Decoction on ventricular remodeling
- VernacularTitle:加减玉女煎抗心室重构的实验研究
- Author:
Jun DU
;
Changxun CHEN
- Publication Type:Journal Article
- Keywords:
Jiajian Yun? Decoction;
ventricular remodeling;
heart index;
nitric oxide;
angiotensin Ⅱ
- From:
Chinese Traditional Patent Medicine
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effects and mechanisms of classic prescription Jiajian Yun? Decoction(JJYND) on ventricular remodeling. METHODS: Two kinds of ventricular remodeling model were induced by injecting L-thyroxine intraperitoneally or banding abdominal aorta in rats.The effects of JJYND on heart index(HI) and concentrations of neuroendocrine factors such as serum nitric oxide(NO),myocardium angiotensin Ⅱ(Ang Ⅱ),endothelin-1(ET-1),activities of glutathione peroxidase(GSH-Px),superoxide dismutase(SOD),concentration of myocardium hydroxyproline(Hyp),cross section area of cardiomyocyte were determined. RESULTS: JJYND could significantly reduce the heart index,cardiomyocyte cross section area,elevate serum NO concentration,restrain myocardium Ang Ⅱ,ET-1,Hyp concentrations and improve myocardium GSH-Px、SOD activities. CONCLUSION: Prescription JJYND has good effects on attenuating ventricular remodeling.
