Absorption of irisquinone-Hydroxypropyl-?-Cyclodextrin Inclusion Complex in intestinal and its pharmacokinetics in rats
- VernacularTitle:马蔺子素/羟丙基-?-环糊精包合物的大鼠小肠吸收及体内药代动力学
- Author:
Xuenong ZHANG
;
Lihua TANG
;
Ping WANG
;
Qiang ZHANG
- Publication Type:Journal Article
- Keywords:
irisquinone;
inclusion complex;
intestinal absorption;
pharmacokinetic
- From:
Chinese Traditional Patent Medicine
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the intestinal uptake of risquinone in two dosage forms-capsule and irisquinone-?-hydroxyprol-?-cyclodextrin(HP-?-CD) in rats and its pharmacokinetics. METHODS: Comparing with capsule,the accumulation uptake of irisquinone from HP-?-CD inclusion complex were tested in suit in vivo and the correspondence between pharmacokinetics behavior and uptake of irisquinone in rats were simultaneously analysised. RESULTS: The intestinal absorption rate of irisquinone were 0.047 h~(-1) to capsule and 0.180 h~(-1) to irisquinone-HP-?-CD,respectively.The intestinal uptake of irisquinone in rats was positive correlation with its release from capsule in vitro.The accumulated uptake of irisquinone were 29.58% from capsule and 69.63 % from irisquinone-HP-?-CD.The pharmacokinetics of irisquinone in two formulas were coincidence with one-compartment model in rats.The absorption half life(T_(1/2(ka))) was 0.23 h to irisquinone-HP-?-CD and 0.49 h to capsule.The relative bioavailability of irisquinone-HP-?-CD was 133.9%. CONCLUSION: Inclusion complex may enhance intestinal uptake of drug and improve its bioavailability.
