The effect of X-irradiation on adhesion molecules and their related biological characteristics of A549 human lung adenocarcinoma cell line
- VernacularTitle:X射线对肺腺癌细胞粘附分子及其相关生物学特性的影响
- Author:
Xiao LIU
- Publication Type:Journal Article
- Keywords:
X-irradiation;
A549;
E-cadherin;
?-catenin;
Metastasis
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of X-irradiation on Adhesion molecules and their related biological characteristics of Human Lung.Methods:A549 cells were irradiated with varying doses of X-rays.MTT assay was employed to evaluate the effects of X-irradiation on the proliferative inhibition of A549 cells.The immunocytochemical method was employed to analyze the protein expression levels of E-cadherin and ?-catenin.The transwell chambers were employed to evaluate the invasion of A549 cells.Results:X-irradiation could inhibit the proliferation of A549 cells in a dose-dependent manner.The protein expression of E-cadherin and ?-catenin in A549 were higher than that in control group(P
