Experimental Study of Shengjiang Powder on Treating Acute Lung Injury
- VernacularTitle:升降散治疗急性肺损伤作用的实验研究
- Author:
Jiasong CHANG
;
Kaifeng WEI
;
Yun PAN
- Publication Type:Journal Article
- Keywords:
SHENGJIANG POWDER/pharmacology;
ACUTE LUNG INJURY/TCD therapy;
LUNG/pathology;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic mechanism of Shengjiang Powder(SP)on acute lung injury.Methods Forty healthy SD male rats were divided into 3 groups randomly: normal group,model group,and SP group.After administration for 6 days,acute lung injury rat models were established by injecting lipopolysaccharide(LPS)into sublingual vein.Lung histological sections were prepared for the detection of NF-?B expression by immmunohistochemistry.The images of the lung histological sections were captured and the average gray values of nucleus of endothelial cells in lung micrangium were measured.Results Compared with the model group,SP could depress the expression of NF-?B in the nucleus of lung microvascular endothelial cells,and statistical difference existed between the two groups(P
