Effect of Baogan Ning on Hepatic Leptin Receptor and Its JAK2/STAT3 Message Pathway in Rats with Hepatic Fibrosis
- VernacularTitle:保肝宁对肝纤维化模型大鼠肝组织瘦素受体及其JAK2/STAT3信号通路的影响
- Author:
Songqi HE
;
Bin WEN
;
Zhiping LV
;
Liying HOU
- Publication Type:Journal Article
- Keywords:
BAOGAN NING /pharmacology;
HEPATIC FIBROSIS/TCD therapy;
PROTEIN EXPRESSION;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the anti-hepatic-fibrosis mechanism of Baogan Ning(BN).Methods Fifty Wistar rats were randomized into 5 groups: normal group,model group,high-and low-dosage BN groups(35.4 and 17.7 g/kg respectively),and colchicine group(0.11mg/kg).Rat models of hepatic fibrosis were induced by multiplex factors.Hepatic protein was extracted,and the expression of hepatic leptic receptors of OB-Rb,JAK2 and STAT3 was detected with Western Blot method.Results The protein expression was not obvious in the normal group,and the color of protein band in the medication groups was light but dark in the model group.Compared with the normal group,the expression of OB-Rb,JAK2 and STAT3 increased in the model group.However,the expression of OB-Rb,JAK2 and STAT3 decreased in the medication groups as compared with the model group.And the expression of OB-Rb,JAK2 and STAT3 decreased in the BN groups as compared with the colchicines group.Conclusion The anti-hepatic-fibrosis mechanism of Baogan Ning is probably related with the inhibition of OB-Rb expression,thus inhibit the JAK2/STAT3 message pathway.
