Screening the Effective Component of Rhizoma Tupistrae Chinensis with Inhibiting Angiogenesis
- VernacularTitle:竹根七中具有血管生成抑制作用有效成分的筛选
- Author:
Maixia MENG
;
Zhifeng YANG
;
Langchong HE
- Publication Type:Journal Article
- Keywords:
Rhizoma Tupistrae chinensis;
cell membrane chromatography;
ECV304;
inhibiting angiogenesis
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discover the effective component of Rhizoma Tupistrae chinensis with inhibiting angiogenesis. Methods Several parts of Rhizoma Tupistrae chinensis were obtained by using different extraction solvents. They were screened by the model of ECV304 cell membrane chromatography with anti-VEGF antibody as a control drug. The inhibition of effective component (ZGQ-C) on ECV304 proliferation in vitro was examined by MTT assay. Results The inhibition rate (40.51%,51.11%,63.54%,74.32%,81.26%) was correlated with the ZGQ-C concentration. The ECV304 cell had significantly changed in morphology. Conclusion The ZGQ-C is an effective component for inhibiting angiogenesis. The screening results on the model have a good correlation with that of MTT assay.
